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- Title
Long-range charge transport in single G-quadruplex DNA molecules.
- Authors
Livshits, Gideon I.; Stern, Avigail; Rotem, Dvir; Porath, Danny; Borovok, Natalia; Eidelshtein, Gennady; Kotlyar, Alexander B.; Migliore, Agostino; Penzo, Erika; Wind, Shalom J.; Di Felice, Rosa; Skourtis, Spiros S.; Cuevas, Juan Carlos; Gurevich, Leonid
- Abstract
DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to differences in the measured molecules and experimental set-ups, and transporting significant current through individual DNA-based molecules remains a considerable challenge. Here, we report reproducible charge transport in guanine-quadruplex (G4) DNA molecules adsorbed on a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured in the G4-DNA over distances ranging from tens of nanometres to more than 100 nm. Our experimental results, combined with theoretical modelling, suggest that transport occurs via a thermally activated long-range hopping between multi-tetrad segments of DNA. These results could re-ignite interest in DNA-based wires and devices, and in the use of such systems in the development of programmable circuits.
- Subjects
QUADRUPLEX nucleic acids; DNA; POLYMERS; MOLECULAR electronics; ELECTRONIC equipment
- Publication
Nature Nanotechnology, 2014, Vol 9, Issue 12, p1040
- ISSN
1748-3387
- Publication type
Article
- DOI
10.1038/nnano.2014.246