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- Title
Factors Influencing Platelet Apheresis Yield and Effects of Donation among Platelet Apheresis Donors.
- Authors
Muthalib, Nazri; Ahmed, Suhair Abbas; Noor, Noor Haslina Mohd; Bahar, Rosnah; Yusoff, Shafini Mohamed; Sudin, Aziee; Ramli, Marini
- Abstract
Introduction: The development of transfusion medicine involving single donor apheresis (SDP) or platelet apheresis has many advantages especially producing high platelet yield. The aim of the study was to investigate the donor and procedure (machine related) factors influencing the platelet apheresis yield. Materials and Methods: It was a prospective study involving thirty-five apheresis blood donors. Age, height, weight, frequency of donation, pre donation haemoglobin level, pre donation platelet count and ABO blood group were included as donor related variables. Anticoagulation infusion rate, processing time and plasma volume collected were assessed as procedure related parameters. We evaluated the post-donation effectiveness by studying the effect of platelet count, haemoglobin level, and haematocrit count and serum ferritin. Results: The platelet apheresis yield correlated positively with pre donation platelet count (r = 0.596) and negatively with height (r = -0.338). Anticoagulation infusion rate and processing time had a positive impact on the platelet apheresis yield. There was a significant difference between pre- and post-donation of platelet count, haemoglobin level and haematocrit count with post-donation had a lower level. A positive correlation between serum ferritin level and platelet apheresis yield was found. Conclusion: Optimization of the platelet apheresis yield by identifying donor and procedure factors related to machine may help in screening donors and selecting certain procedure to obtain high quality and productivity of platelet collection.
- Subjects
BLOOD collection; BLOOD platelets; STATISTICAL correlation; FERRITIN; HEMAPHERESIS; LONGITUDINAL method
- Publication
International Medical Journal, 2020, Vol 27, Issue 6, p700
- ISSN
1341-2051
- Publication type
Article