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- Title
Terminal Field and Firing Selectivity of Cholecystokinin- Expressing Interneurons in the Hippocampal CA3 Area.
- Authors
Lasztóczi, Bálint; Tukker, John J.; Somogyi, Peter; Klausberger, Thomas
- Abstract
Hippocampal oscillations reflect coordinated neuronal activity on many timescales. Distinct types of GABAergic interneuron participate in the coordination of pyramidal cells over different oscillatory cycle phases. In theCA3area,whichgenerates sharpwavesandgammaoscillations, the contribution of identified GABAergic neurons remains to be defined. We have examined the firing of a family of cholecystokinin-expressing interneurons during network oscillations in urethane-anesthetized rats and compared them with firing of CA3 pyramidal cells. The position of the terminals of individual visualized interneurons was highly diverse, selective, and often spatially coaligned with either the entorhinal or the associationalinputstoareaCA3.Thespiketiminginrelationtothetaandgammaoscillationsandsharpwaveswascorrelatedwiththeinnervated pyramidal cell domain. Basket and dendritic-layer-innervating interneurons receive entorhinal and associational inputs and preferentially fire on the ascending theta phase, when pyramidal cell assemblies emerge. Perforant-path-associated cells, driven by recurrent collaterals of pyramidal cells fire on theta troughs, when established pyramidal cell assemblies are most active. In the CA3 area, slow and fast gamma oscillations occurred on opposite theta oscillation phases. Perforant-path-associated and some COUP-TFII-positive interneurons are strongly coupled to both fast and slow gamma oscillations, but basket and dendritic-layer-innervating cells are weakly coupled to fast gamma oscillations only. During sharp waves, different interneuron types are activated, inhibited, or remain unaffected.Wesuggest that specialization in pyramidal cell domain and glutamatergic input-specific operations, reflected in the position of GABAergic terminals, is the evolutionary drive underlying the diversity of cholecystokinin-expressing interneurons.
- Subjects
CHOLECYSTOKININ; GENE expression; HIPPOCAMPUS physiology; NEURONS; BRAIN function localization; LABORATORY rats; DENDRITIC cells; INTERNEURONS
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 49, p18073
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3573-11.2011