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- Title
Control of Epstein-Barr Virus (EBV) in the Oral Cavity Is Associated With Persistence of Oral Human Papillomavirus (HPV)16/18 Among Men From the HPV Infection in Men Study.
- Authors
Dickey, Brittney L; Giuliano, Anna R; Sirak, Bradley; Abrahamsen, Martha; Lazcano-Ponce, Eduardo; Villa, Luisa L; Coghill, Anna E
- Abstract
Background Human papillomavirus (HPV)-related oropharyngeal cancer (OPC) incidence is increasing among men. Biomarkers that can identify oral HPV16/18 infections likely to persist, the obligate precursor for HPV-OPC, are needed. Methods We assessed the association between oral Epstein-Barr virus (EBV) and oral HPV16/18 persistence among 63 men in the HPV Infection in Men Study who tested positive for HPV16/18 at the baseline visit. Control of oral coinfections, including EBV, could serve as a biomarker of immune competence and the ability to control oral HPV. Results Detection of oral EBV was significantly associated with oral HPV16/18 ≥12-month persistence. Conclusions Detection of oral EBV deserves evaluation as a biomarker for oral HPV persistence and HPV-related OPC.
- Subjects
EPSTEIN-Barr virus; PAPILLOMAVIRUSES; OROPHARYNGEAL cancer; MIXED infections; INFECTION
- Publication
Journal of Infectious Diseases, 2023, Vol 227, Issue 2, p256
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiac223