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- Title
Incidence of Malignancies Among Patients With Chronic Hepatitis B in US Health Care Organizations, 2006-2018.
- Authors
Spradling, Philip R; Xing, Jian; Zhong, Yuna; Rupp, Loralee B; Moorman, Anne C; Lu, Mei; Teshale, Eyasu H; Schmidt, Mark A; Daida, Yihe G; Boscarino, Joseph A; Gordon, Stuart C
- Abstract
Hepatitis B virus (HBV) infection causes hepatocellular carcinoma but its association with other cancers is not well established. We compared age-adjusted incidence of primary cancers among 5773 HBV-infected persons with US cancer registries during 2006-2018. Compared with the US population, substantially higher incidence among HBV-infected persons was observed for hepatocellular carcinoma (standardized rate ratio [SRR], 30.79), gastric (SRR, 7.95), neuroendocrine (SRR, 5.88), cholangiocarcinoma (SRR, 4.62), and ovarian (SRR, 3.72) cancers, and non-Hodgkin lymphoma (SRR, 2.52). Clinicians should be aware of a heightened potential for certain nonhepatic malignancies among hepatitis B patients, as earlier diagnosis favors improved survival.
- Subjects
HEPATITIS B; LIVER tumors; HEPATITIS viruses; DISEASE incidence; MEDICAL care; RESEARCH funding; CHRONIC hepatitis B; HEPATOCELLULAR carcinoma; DISEASE complications
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 5, p896
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiac011