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- Title
Burden of Adults Hospitalized With Group B Streptococcal Infection.
- Authors
McLaughlin, John M; Peyrani, Paula; Furmanek, Stephen; Khan, Farid L; Quinn, Angela; Jodar, Luis; Ramirez, Julio; Swerdlow, David L
- Abstract
<bold>Background: </bold>The burden of noninvasive group B Streptococcus (GBS) infections in adults is unknown. We determined population-based rates of hospitalization where invasive or noninvasive GBS infections were identified among US adults in a defined catchment area.<bold>Methods: </bold>We identified adults with clinical and laboratory-confirmed evidence of GBS infection from January 2014 through December 2016 from 6 hospitals in Louisville, Kentucky. Invasive disease was defined as GBS isolated from a normally sterile site.<bold>Results: </bold>Among 1076 adults with GBS infection, the median age was 52 years, 51% were male, and 89% had ≥1 chronic medical condition. The most prevalent infection sites were skin and soft tissue (39%), urinary tract (23%), bone and joint (16%), and bloodstream (11%). Forty percent of infections were polymicrobial. The annual incidence of GBS-associated hospitalization was 73 per 100 000 adults and 68 and 100 per 100 000 for patients aged 18-64 and ≥ 65 years, respectively. For every invasive GBS infection, 3.7 noninvasive infections occurred.<bold>Conclusions: </bold>Our population-based study outlines the full burden of GBS-associated hospitalization in adults and found incidence rates comparable to those of pneumococcal disease, where vaccines are recommended. Noninvasive disease was 3-4 times more common than invasive disease, suggesting that the GBS burden among adults is considerably greater than previously recognized.
- Subjects
LOUISVILLE (Ky.); KENTUCKY; STREPTOCOCCAL diseases; STREPTOCOCCUS agalactiae; ADULTS; INFECTION; URINARY organs; JOINTS (Anatomy); NEONATAL sepsis; STREPTOCOCCAL disease diagnosis; RESEARCH; RESEARCH methodology; DISEASE incidence; EVALUATION research; STREPTOCOCCUS; COMPARATIVE studies; HOSPITAL care; RESEARCH funding
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 7, p1170
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa110