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- Title
Brief Genetics Report/ Mapping Genes Influencing Type 2 Diabetes Risk and BMI in Japanese Subjects.
- Authors
Iwasaki, Naoko; Cox, Nancy J.; Wang, Yan-Qing; Yan-Qing Wang; Schwarz, Peter E.H.; Bell, Graeme I.; Honda, Masashi; Imura, Mitsuo; Ogata, Makiko; Saito, Masayuki; Kamatani, Naoyuki; Iwamoto, Yasuhiko
- Abstract
We have carried out an autosomal genome scan for genes contributing to the development of type 2 diabetes and affecting BMI in the Japanese population (164 families, 256 affected sib-pairs). We found 12 regions that showed nominally significant multipoint evidence of linkage with type 2 diabetes (i.e. logarithm of odds [LOD] score >0.59, P < 0.05): chromosome 1 29.9 cM; chromosome 2 169.6 and 236.8 cM; chromosome 4 104.9 cM; chromosome 5 114.8 cM; chromosome 6 42.3 cM; chromosome 8 15.3 and 93.3 cM; chromosome 9 140.0 cM; chromosome 11 131.6 cM; chromosome 17 36.1 cM; and chromosome 21 48.0 cM. Twelve regions showed nominal multipoint evidence for linkage with log-transformed BMI (1nBMI): chromosome 2 167.9 and 210.5 cM; chromosome 3 185.7 cM; chromosome 4 118.9 and 145.6 cM; chromosome 5 131.9 cM; chromosome 7 7.4 cM; chromosome 10 70.0 cM; chromosome 15 12.8 cM; chromosome 16 30.0 cM; and chromosome 17 47.8 and 100.2 cM. Although none of the regions achieved genome-wide levels of significance, simulation studies showed that we observed more linkage signals than expected if there were no loci contributing to type 2 diabetes or BMI. Eight of the regions showing nominal evidence for linkage with type 2 diabetes have been reported in other genome scans, and seven of the regions showing linkage with InBMI have shown linkage with BMI and BMIrelated traits in other studies. Thus, our results may replicate findings in other studies. They may also indicate new regions of the genome that are involved in the regulation of blood glucose levels or body weight.
- Subjects
TYPE 2 diabetes; GENE mapping
- Publication
Diabetes, 2003, Vol 52, Issue 1, p209
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.52.1.209