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- Title
T-lymphocyte-receptor repertoire of infiltrating T lymphocytes into NOD mouse pancreas.
- Authors
Maeda, Toshiro; Sumida, Takayuki; Kurasawa, Kazuhiro; Tomioka, Hisao; Itoh, Isao; Yoshida, Sho; Koike, Takao; Maeda, T; Sumida, T; Kurasawa, K; Tomioka, H; Itoh, I; Yoshida, S; Koike, T
- Abstract
This study analyzed T-lymphocyte-receptor V beta genes of infiltrating lymphocytes into the pancreases of 12- to 16-wk-old NOD mice with severe insulitis and 5-wk-old mice with mild insulitis by the quantitative polymerase chain reaction method. The V beta transcripts on infiltrating T lymphocytes into pancreases with severe insulitis in older NOD mice were diverse. In contrast, the V beta 11 gene transcript was predominantly expressed on T lymphocytes in the pancreas in younger NOD mice with mild insulitis, suggesting the possible role of V beta 11+ T lymphocytes in triggering insulitis in this species.
- Publication
Diabetes, 1991, Vol 40, Issue 12, p1580
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.40.12.1580