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- Title
Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.
- Authors
Prasla, Zohra; Sutliff, Roy L.; Sadikot, Ruxana T.
- Abstract
The incidence and prevalence of nontuberculous mycobacteria (NTM) lung disease is rising worldwide and accounts for most clinical cases of NTM disease. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary host cells that initiate an immune response to NTM. Defining the molecular events that govern the control of infection within macrophages is fundamental to understanding the pathogenesis of NTM disease. Here, we review key macrophage host signaling pathways that contribute to the host immune response to pulmonaryNTMinfections. In this review, we focus primarily on NTM that are known to cause lung disease, including Mycobacterium avium intracellulare, M. abscessus, and M. kansasii.
- Subjects
MYCOBACTERIAL diseases; LUNG diseases; DISEASE prevalence; DISEASE incidence; MACROPHAGES
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2020, Vol 63, Issue 2, p144
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2019-0241TR