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- Title
Theoretical study on percutaneous absorption of olmesartan medoxomil: The pH control effect.
- Authors
Mbah, Chika J.; Onah, Chinwe M.; Asogwa, Queendalyn E.
- Abstract
Purpose: To predict the percutaneous absorption of olmesartan medoxomil using dermal parameters obtained under pH control. Methods: Partition coefficient of olmesartan medoxomil was determined in a chloroform-buffer system by shake flask method at room temperature. The test was carried out under different pH conditions. Established mathematical equations were utilized to calculate percutaneous absorption parameters, including the permeability coefficient of the drug through the skin, maximum flux through the skin, activation energy involved in the partitioning of the drug in the chloroform-buffer system, and diffusion coefficient of the drug through skin. Results: At pH 2.0, the drug gave the highest logarithm partition coefficient when compared to other pH values investigated as well as distilled water (control). The mean logarithm partition coefficient of the drug (4.36 ± 0.06) at pH 2.0 compared well to the mean logarithm partition coefficient of the drug (4.15 ± 0.07) in distilled water at 95 % level. Statistical analysis indicated that null hypothesis was rejected at this confidence level. Test of significance was not carried out on the other parameters including maximum flux, activation energy and diffusion coefficient data because they were estimated from the experimental partition coefficient. Conclusion: Percutaneous absorption of olmesartan medoxomil using dermal parameters obtained under pH control can be predicted. As the rate of penetration into the skin is quantitatively assessed by the use of permeability coefficient, the results predict significant percutaneous absorption of olmesartan medoxomil.
- Subjects
SKIN absorption; PH effect; ACTIVATION energy; DISTILLED water; DIFFUSION coefficients; NULL hypothesis
- Publication
Tropical Journal of Pharmaceutical Research, 2021, Vol 20, Issue 12, p2463
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v20i12.1