We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination.
- Authors
Herrero-Fernández, Inés; Rosado-Sánchez, Isaac; Genebat, Miguel; Tarancón-Díez, Laura; Rodríguez-Méndez, María Mar; Pozo-Balado, María Mar; Lozano, Carmen; Ruiz-Mateos, Ezequiel; Leal, Manuel; Pacheco, Yolanda M.; Herrero-Fernández, Inés; Rosado-Sánchez, Isaac; Tarancón-Díez, Laura; Rodríguez-Méndez, María Mar; Pozo-Balado, María Mar
- Abstract
<bold>Background: </bold>Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different immunological parameters that could account for this effect.<bold>Methods: </bold>We analysed baseline samples of vaccinated subjects under 50 years old (n = 41). We characterized the maturational subsets and the expression of activation, senescence and prone-to-apoptosis markers on CD4 T-cells; we also quantified T-regulatory cells (Treg) and dendritic cell (DC) subsets. We used binary logistic regression to evaluate the immunological impact of MVC-cART, correlation with MVC exposure and linear regression for association with the magnitude of the HBV vaccine response.<bold>Results: </bold>HIV-infected subjects on MVC-cART prior to vaccination showed increased recent thymic emigrants levels and reduced myeloid-DC levels. A longer exposure to MVC-cART was associated with lower frequencies of Tregs and activated and proliferating CD4 T-cells. Furthermore, the frequencies of activated and proliferating CD4 T-cells were inversely associated with the magnitude of the HBV vaccine response.<bold>Conclusion: </bold>The beneficial effect of MVC-cART in the HBV vaccine response in subjects below 50 years old could be partially mediated by its reducing effect on the frequencies of activated and proliferating CD4 T-cells prior to vaccination.
- Subjects
CD4 antigen; T cells; HIV-positive persons; HEPATITIS B vaccines; LOGISTIC regression analysis; THERAPEUTICS
- Publication
Journal of Translational Medicine, 2018, Vol 16, Issue 1, pN.PAG
- ISSN
1479-5876
- Publication type
journal article
- DOI
10.1186/s12967-018-1617-1