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- Title
Impact of pancreatic resection in patients with liver cirrhosis.
- Authors
Hiroki Teraoku; Yuji Morine; Tetsuya Ikemoto; Yu Saito; Shinichiro Yamada; Yuhei Waki; Shohei Okikawa; Katsuki Miyazaki; Chiharu Nakasu; Takayuki Noma; Akira Takahashi; Mitsuo Shimada
- Abstract
Background : Several reports have shown a high mortality rate in patients with liver cirrhosis (LC) who undergo pancreaticoduodenectomy, however, there are few reports on its long-term prognosis. Methods : Twelve patients with LC who had undergone pancreatic resection were enrolled. To compare clinicopathological variables, 159 non-LC patients who had undergone resection for pancreatic cancer were enrolled. Results : Pancreaticoduodenectomy (PD) was performed in 5 LC patients and distal pancreatectomy (DP) was performed in 7 LC patients. Patients in the LC group had more co-morbidities, lower platelet counts and higher Fib4 index than the non-LC group. The postoperative complication rate was higher in the LC group (83.3% vs 47.8%). While the postoperative hospital stay and 30-day mortality rate were not different, the 90-day mortality rate was higher in the LC group (25.0% vs 2.5% ; p<0.01). Comparison by operative procedure showed no significant differences of postoperative outcomes in DP cases. However, in PD cases, postoperative complications were more frequent (100% vs 42.3%) and 90-day mortality was higher (40.0% vs 2.9% ; p<0.01) in the LC group. Conclusions : PD resulted in higher postoperative morbidity and mortality rates in patients with LC compared with non-LC patients. DP could be tolerated in the LC patients.
- Subjects
CIRRHOSIS of the liver; PANCREATICODUODENECTOMY; SURGICAL complications; PLATELET count; POSTOPERATIVE period
- Publication
Journal of Medical Investigation, 2023, Vol 70, Issue 1/2, p189
- ISSN
1343-1420
- Publication type
Article
- DOI
10.2152/jmi.70.189