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- Title
Significantly reducing blood loss via a peri-articular injection of tranexamic acid during total knee arthroplasty: a retrospective study.
- Authors
Yu-Kuan Lin; Shang-Wen Tsai; Po-Kuei Wu; Chao-Ming Chen; Jesse Chieh-Szu Yang; Cheng-Fong Chen; Wei-Ming Chen; Lin, Yu-Kuan; Tsai, Shang-Wen; Wu, Po-Kuei; Chen, Chao-Ming; Yang, Jesse Chieh-Szu; Chen, Cheng-Fong; Chen, Wei-Ming
- Abstract
<bold>Background: </bold>The administration of an intra-articular injection (IAI) of tranexamic acid (TXA) has been demonstrated to be effective in reducing both blood loss and transfusion rate during total knee arthroplasty (TKA); however, few studies have reported the efficiency of a peri-articular injection (PAI) of TXA. We studied the efficiency of a PAI of TXA in reducing blood loss during TKA.<bold>Methods: </bold>Fifty patients undergoing primary simultaneous bilateral TKA were enrolled in this retrospective study. The right knee received a PAI of 1 g of TXA (Group I), and the left knee received an IAI of 1 g of TXA (Group II). The clinical outcome measures were a change in blood loss from Hemovac drains and surgical time.<bold>Results: </bold>The decrease in blood loss from the Hemovac was significantly lower in Group I (460.1 ± 36.79 vs. 576.0 ± 34.01, P < 0.001) than in Group II, and no significant difference in surgical times was observed. The blood transfusion rate in the present study was 16 %.<bold>Conclusions: </bold>A PAI of TXA may reduce blood loss more efficiently than an IAI of TXA during TKA without increased complications such as surgical site infection, poor wound healing, skin necrosis, pulmonary embolism, and deep vein thrombosis.
- Subjects
TOTAL knee replacement; TRANEXAMIC acid; INJECTIONS; SURGICAL site infections; VENOUS thrombosis; PREVENTION of surgical complications; HEMORRHAGE prevention; SURGICAL blood loss; INTRAVENOUS therapy; RETROSPECTIVE studies; SURGICAL complications; INTRA-articular injections; ANTIFIBRINOLYTIC agents; HEMORRHAGE
- Publication
BMC Musculoskeletal Disorders, 2021, Vol 22, Issue 1, p1
- ISSN
1471-2474
- Publication type
journal article
- DOI
10.1186/s12891-021-04591-0