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- Title
Hepatoprotective effect of licorice, the root of Fischer, in alcohol-induced fatty liver disease.
- Authors
Jae-Chul Jung; Yun-Hee Lee; Sou Hyun Kim; Keuk-Jun Kim; Kyung-Mi Kim; Seikwan Oh; Young-Suk Jung
- Abstract
Background: Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative activity in tert-butyl hydroperoxide--induced oxidative liver damage. In this study, we evaluated the effect of licorice on chronic alcohol-induced fatty liver injury mediated by inflammation and oxidative stress. Methods: Raw licorice was extracted, and quantitative and qualitative analysis of its components was performed by using LC--MS/MS. Mice were fed a liquid alcohol diet with or without licorice for 4 weeks. Results: We have standardized 70 % fermented ethanol extracted licorice and confirmed by LC-MS/MS as glycyrrhizic acid (GA), 15.77 ± 0.34 µg/mg; liquiritin (LQ), 14.55 ± 0.42 µg/mg; and liquiritigenin (LG), 1.34 ± 0.02 µg/mg, respectively. Alcohol consumption increased serum alanine aminotransferase and aspartate aminotransferase activities and the levels of triglycerides and tumor necrosis factor (TNF)-α. Lipid accumulation in the liver was also markedly induced, whereas the glutathione level was reduced. All these alcohol-induced changes were effectively inhibited by licorice treatment. In particular, the hepatic glutathione level was restored and alcohol-induced TNF-α production was significantly inhibited by licorice. Conclusion: Taken together, our data suggests that protective effect of licorice against alcohol-induced liver injury may be attributed to its anti-inflammatory activity and enhancement of antioxidant defense.
- Subjects
COMPLICATIONS of alcoholism; GLYCYRRHIZA; ANTIOXIDANT analysis; ALCOHOLIC liver diseases; ANIMAL experimentation; ANTI-inflammatory agents; ASPARTATE aminotransferase; CALIBRATION; ETHANOL; GLUTATHIONE; LIPIDS; LIQUID chromatography; MASS spectrometry; MICE; MOLECULAR structure; RESEARCH funding; PLANT roots; STATISTICS; TUMOR necrosis factors; DATA analysis; ALANINE aminotransferase; DESCRIPTIVE statistics; ONE-way analysis of variance; THERAPEUTICS
- Publication
BMC Complementary & Alternative Medicine, 2016, p1
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/s12906-016-0997-0