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- Title
Neuroprotective Effect of PACAP against Kainic Acid-Induced Neurotoxicity in Rat Retina.
- Authors
SEKI, TAMOTSU; NAKATANI, MASAYOSHI; TAKI, CHISATO; SHINOHARA, YUKO; OZAWA, MOTOKI; NISHIMURA, SHIGERU; ITO, HIROYUKI; SHIODA, SEIJI
- Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.
- Subjects
RATS; RETINA; NEUROTOXICOLOGY; KAINIC acid; PEPTIDE hormones; RETINAL ganglion cells
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1070, Issue 1, p531
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1317.074