We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Molecular Mechanism of the Life and Death of the Osteoclast.
- Authors
TANAKA, SAKAE; MIYAZAKI, TSUYOSHI; FUKUDA, AKIRA; AKIYAMA, TORU; KADONO, YUHO; WAKEYAMA, HIDETOSHI; KONO, SHINJIRO; HOSHIKAWA, SHINYA; NAKAMURA, MASAKI; OHSHIMA, YASUSHI; HIKITA, ATSUHIKO; NAKAMURA, ICHIRO; NAKAMURA, KOZO
- Abstract
The life span of osteoclasts is critically regulated by various cytokines, and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This article will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advances in this field with an emphasis on the role of intracellular signaling pathways.
- Subjects
BONE cells; CYTOKINES; APOPTOSIS; DIPHOSPHONATES; THERAPEUTICS
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1068, Issue 1, p180
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1346.020