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- Title
Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals.
- Authors
CHARTREL, NICOLAS; BRUZZONE, FEDERICA; DUJARDIN, CYNTHIA; LEPRINCE, JEROME; TOLLEMER, HELENE; ANOUAR, YOUSSEF; VALLARINO, MAURO; COSTENTIN, JEAN; VAUDRY, HUBERT
- Abstract
In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
- Subjects
FROG anatomy; BRAIN research; NEUROPEPTIDES; LABORATORY rats; PEPTIDES
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1040, Issue 1, p80
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1327.009