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- Title
Relative Atrophy of the Flocculus and Ocular Motor Dysfunction in SCA2 and SCA6.
- Authors
YING, S H; CHOI, S I; LEE, M; PERLMAN, S L; BALOH, R W; TOGA, A W; ZEE, D S
- Abstract
Two hereditary ataxia syndromes show distinct profiles of regionspecific atrophy and ocular motor deficits. Selective pontine atrophy is associated with slowed saccades in ataxin-2 mutations, and selective floccular atrophy is associated with impaired pursuit and gaze-holding abnormalities in Ca(V)2.1 mutations. Although the flocculus seems to be spared relative to the pons in ataxin-2 mutations, and pursuit and gaze-holding appear to be relatively normal, these can be difficult to assess at the bedside, as corrective saccades are also slow and hard to discern. Here, we show the presence of significant floccular atrophy compared with controls in both ataxin-2 and Ca(V)2.1 mutations, which raises the possibility that abnormalities of smooth pursuit or gazeholding are present in both conditions.
- Subjects
SACCADIC eye movements; ATAXIA; MOVEMENT disorders; MUSCULAR atrophy; MOTOR neurons
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1039, Issue 1, p430
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1325.040