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- Title
Gamma knife radiosurgery for glomus jugulare tumors: therapeutic advantages of minimalism in the skull base.
- Authors
Sharma MS; Gupta A; Kale SS; Agrawal D; Mahapatra AK; Sharma BS; Sharma, Manish S; Gupta, A; Kale, S S; Agrawal, D; Mahapatra, A K; Sharma, B S
- Abstract
<bold>Context: </bold>Glomus jugulare (GJ) tumors are paragangliomas found in the region of the jugular foramen. Surgery with/without embolization and conventional radiotherapy has been the traditional management option.<bold>Aim: </bold>To analyze the efficacy of gamma knife radiosurgery (GKS) as a primary or an adjunctive form of therapy.<bold>Settings and Design: </bold>A retrospective analysis of patients who received GKS at a tertiary neurosurgical center was performed.<bold>Materials and Methods: </bold>Of the 1601 patients who underwent GKS from 1997 to 2006, 24 patients with GJ underwent 25 procedures.<bold>Results: </bold>The average age of the cohort was 46.6 years (range, 22-76 years) and the male to female ratio was 1:2. The most common neurological deficit was IX, X, XI cranial nerve paresis (15/24). Fifteen patients received primary GKS. Mean tumor size was 8.7 cc (range 1.1-17.2 cc). The coverage achieved was 93.1% (range 90-97%) using a mean tumor margin dose of 16.4 Gy (range 12-25 Gy) at a mean isodose of 49.5% (range 45-50%). Thirteen patients (six primary and seven secondary) were available for follow-up at a median interval of 24 months (range seven to 48 months). The average tumor size was 7.9 cc (range 1.1-17.2 cc). Using a mean tumor margin dose of 16.3 Gy (range 12-20 Gy) 93.6% coverage (range 91-97%) was achieved. Six patients improved clinically. A single patient developed transient trigeminal neuralgia. Magnetic resonance imaging follow-up was available for 10 patients; seven recorded a decrease in size. There was no tumor progression.<bold>Conclusions: </bold>Gamma knife radiosurgery is a safe and effective primary and secondary modality of treatment for GJ.
- Publication
Neurology India, 2008, Vol 56, Issue 1, p57
- ISSN
0028-3886
- Publication type
journal article