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- Title
Electrophilic Trifluoromethylthiolation of Carbonyl Compounds.
- Authors
Alazet, Sébastien; Zimmer, Luc; Billard, Thierry
- Abstract
A general method for the α-trifluoromethylthiolation of carbonyl compounds, without prefunctionalization, has been developed. Aldehydes, ketones, esters, amides, keto-esters, alkaloids, and steroids have been trifluoromethylthiolated with good yields. This work, proposing a new reagent for electrophilic trifluoromethylthiolation, provides a route towards the original synthesis of various trifluoromethylthiolated molecules for further applications.
- Subjects
CARBONYL compounds; CHEMICAL yield; ALDEHYDES; ESTERS; KETONES; AMIDES; ALKALOIDS; STEROIDS
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 28, p8589
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201403409