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- Title
Role of dynamic contrast-enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER-positive, HER2-negative, node-negative invasive breast cancer.
- Authors
Shin, Gi Won; Zhang, Yang; Kim, Min Jung; Su, Min‐Ying; Kim, Eun‐Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Park, Vivian Youngjean; Su, Min-Ying; Kim, Eun-Kyung
- Abstract
<bold>Background: </bold>Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments.<bold>Purpose: </bold>To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer.<bold>Study Type: </bold>Retrospective.<bold>Population: </bold>In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm.<bold>Field Strength/sequence: </bold>3T, T1 -weighted DCE sequence.<bold>Assessment: </bold>BPE of the contralateral breast was assessed qualitatively by two dedicated radiologists and quantitatively (using region-of-interest and automatic breast segmentation).<bold>Statistical Tests: </bold>Cox regression analysis was used to determine associations with recurrence-free survival (RFS) and distant metastasis-free survival (DFS). Interobserver variability for parenchymal enhancement was assessed using kappa statistics and intraclass correlation coefficient (ICC).<bold>Results: </bold>The median follow-up time was 75.8 months. Multivariate analysis showed receipt of total mastectomy (hazard ratio [HR]: 5.497) and high Ki-67 expression level (HR: 5.956) were independent factors associated with worse RFS (P < 0.05). Only a high Ki-67 expression level was associated with worse DFS (HR: 3.571, P = 0.045). BPE assessments were not associated with outcome (RFS [qualitative BPE: P = 0.75, 0.92 for readers 1 and 2; quantitative BPE: P = 0.38-0.99], DFS, [qualitative BPE: P = 0.41, 0.16 for readers 1 and 2; quantitative BPE: P = 0.68-0.99]). For interobserver variability, there was good agreement between qualitative (κ = 0.700) and good to perfect agreement for most quantitative parameters of BPE.<bold>Data Conclusion: </bold>Contralateral BPE showed no association with survival outcome in patients with ER-positive, HER2-negative, node-negative invasive breast cancer. A high Ki-67 expression level was associated with both worse recurrence-free and distant metastasis-free survival.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2018;48:1678-1689.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 48, Issue 6, p1678
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26176