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- Title
Gadolinium-free extracellular MR contrast agent for tumor imaging.
- Authors
Nofiele, Joris Tchouala; Haedicke, Inga E.; Zhu, Yong Le K.; Zhang, Xiao‐an; Cheng, Hai‐Ling Margaret
- Abstract
Purpose To evaluate a new formulation of manganese porphyrin as a potential gadolinium (Gd)-free extracellular magnetic resonance imaging (MRI) contrast agent for dynamic contrast-enhanced (DCE) MRI of tumors. Materials and Methods A previously reported new contrast agent, MnTCP, was evaluated in six female tumor-bearing nude rats. MRI was performed on a 3 T clinical scanner 3 to 4 weeks after inoculation of breast tumor cells in the mammary fat pads. Gd-DTPA was injected intravenously, followed by injection of MnTCP at least 2 hours later (both at 0.05 mmol/kg). T1 relaxation time measurements and DCE-MRI were performed. Results Enhancement and clearance patterns were visually similar between MnTCP and Gd-DTPA. However, relative R1 increases in all 11 tumors were larger for MnTCP over 60 minutes postcontrast, the difference being significant as late as 20 minutes ( R1post/ R1pre = 1.42 ± 0.15 for MnTCP vs. 1.20 ± 0.08 for Gd-DTPA, P < 0.05). R1-related effects for MnTCP were largely reduced after 60 minutes ( R1post/ R1pre = 1.13 ± 0.07) and completely gone within 24 hours ( R1post/ R1pre = 0.97 ± 0.06). DCE-MRI revealed a consistently larger (1.5 to over 2-fold) peak enhancement and higher values of the steepest slope, time-to-peak, and AUC60 in all tumors with MnTCP ( P < 0.01). Conclusion MnTCP is an alternative to extracellular Gd agents for tumor imaging, offering sensitive detection and rapid renal clearance. J. Magn. Reson. Imaging 2015;41:397-403.© 2013 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2015, Vol 41, Issue 2, p397
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.24561