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- Title
Naturally occurring enzyme inhibitors and their pharmaceutical applications.
- Authors
Ata, Athar; Naz, Samina; Elias, Evan M.
- Abstract
Enzyme inhibitors play a significant role in the drug discovery process. For instance, acetylcholinesterase (AChE) inhibitors have applications in curing Alzheimer's disease (AD), senile dementia, ataxia, myasthenia gravis, and Parkinson's disease. Glutathione S-transferase (GST) inhibitors have applications as adjuvants to overcome anticancer and antiparasitic drug resistance problems. Compounds inhibiting the activity of α-glucosidase are used to treat type 2 diabetes mellitus and obesity problems. This article describes the identification of natural products exhibiting AChE, GST, and α-glucosidase inhibitory activities from medicinally important plants. Additionally, structure-activity relationship (SAR) studies of these newly discovered enzyme inhibitors are also discussed.
- Subjects
ENZYME inhibitors; ACETYLCHOLINESTERASE; ALZHEIMER'S disease treatment; SENILE dementia treatment; GLUCOSIDASES; ARTOCARPUS; DRUG resistance; ANTINEOPLASTIC agents
- Publication
Pure & Applied Chemistry, 2011, Vol 83, Issue 9, p1741
- ISSN
0033-4545
- Publication type
Article
- DOI
10.1351/PAC-CON-10-11-16