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- Title
Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors.
- Authors
Maschuw, Katja; Fendrich, Volker; Langer, Peter; Volland, C.; Ramaswamy, Annette; Bartsch, Detlef
- Abstract
Background: Sporadic malignant non-functioning pancreatic endocrine tumors (NF-PETs) are an important subset of pancreatic neoplasms. The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up. Patients and methods: From 1988 to 2009, 51 patients were treated for sporadic malignant NF-PETs. Forty-one patients who underwent tumor resection were retrospectively attributed according to the date of the initial diagnosis, group 1: 1988-1999 vs. group 2: 2000-2009. Results: Cross-sectional imaging led to positive prediction of NF-PETs in all patients. Curative resection was achieved in 76%. Synchronous metastases were present in 56% with a positive prediction of 43%. In group 1, the mean reported CT-determined tumor size was 56 vs. 54 mm in group 2 ( p = 0.89). Synchronous metastases were present in 61% in group 1 vs. 57% ( p = 0.99) in group 2. Metachronous metastases were recorded in 39% in group 1 vs. 43% ( p = 0.84) in group 2. The mean interval from initial resection to diagnosis of metastatic disease was significantly shorter ( p = 0.01) in patients from group 1 (14 vs. 61 months). Cumulative 5- and 10-year survival rates were 77% and 72% in group 1 vs. a 5-year survival rate of 66% in group 2. Conclusion: So far, improved CT-based imaging has no impact on earlier detection of initial synchronous metastases in sporadic malignant NF-PETs, while metachronous metastases are detected earlier.
- Subjects
PANCREATIC tumors; TOMOGRAPHY; DIAGNOSTIC imaging; ONCOLOGIC surgery; METASTASIS; DIAGNOSIS
- Publication
Langenbeck's Archives of Surgery, 2011, Vol 396, Issue 8, p1181
- ISSN
1435-2443
- Publication type
Article
- DOI
10.1007/s00423-011-0748-0