We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea.
- Authors
Liu, Lanying; Guan, Fuqin; Chen, Yu; Wang, Fan; Chen, Pengxu; Yin, Min; Wang, Bi; Li, Linwei; Wang, Qizhi; Gu, Yonghua; Feng, Xu
- Abstract
Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-β-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3–7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes.
- Subjects
TYPE 2 diabetes; GLYCOSIDES
- Publication
Molecules, 2022, Vol 27, Issue 18, p5753
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27185753