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- Title
The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?
- Authors
de Oliveira, Fábio Rodrigues; da Silva, Nágila Monteiro; Hamoy, Moisés; Crespo-López, Maria Elena; Ferreira, Irlon Maciel; da Silva, Edilene Oliveira; de Matos Macchi, Barbarella; do Nascimento, José Luiz Martins
- Abstract
Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research into new anticonvulsant drugs (ACDs). The GABAergic system is the main inhibitory system of the brain and has a central role in seizures and the screening of new ACD candidates. It has been demonstrated that the action of agents on endocannabinoid receptors modulates the balance between excitatory and inhibitory neurotransmitters; however, studies on the anticonvulsant properties of endocannabinoids from plant oils are relatively scarce. The Amazon region is an important source of plant oils that can be used for the synthesis of new fatty acid amides, which are compounds analogous to endocannabinoids. The synthesis of such compounds represents an important approach for the development of new anticonvulsant therapies.
- Subjects
VEGETABLE oils; CANNABINOIDS; CANNABINOID receptors; ANTICONVULSANTS; EPILEPSY; SEIZURES (Medicine); AMIDES
- Publication
Molecules, 2022, Vol 27, Issue 11, p3595
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27113595