We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways.
- Authors
Jung, Young Yun; Shanmugam, Muthu K.; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Shair, Omar H.M.; Um, Jae-Young; Sethi, Gautam; Ahn, Kwang Seok; Miguel, Maria da Graça Costa G.
- Abstract
Fangchinoline (FCN) derived from Stephaniae tetrandrine S. Moore can be employed to treat fever, inflammation, rheumatism arthralgia, edema, dysuria, athlete's foot, and swollen wet sores. FCN can exhibit a plethora of anti-neoplastic effects although its precise mode of action still remains to be deciphered. Nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumor cells. The effect of FCN on NF-κB and AP-1 signaling cascades and its downstream functions was deciphered using diverse assays in both human chronic myeloid leukemia (KBM5) and multiple myeloma (U266). FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-κB, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of IκB kinase (IKK) and p65. Furthermore, FCN could also cause significant enhancement in TNFα-driven apoptosis as studied by various molecular techniques. Thus, FCN may exhibit potent anti-neoplastic effects by affecting diverse oncogenic pathways and may be employed as pro-apoptotic agent against various malignancies.
- Subjects
CHRONIC myeloid leukemia; ALKALOIDS; APOPTOSIS; MULTIPLE myeloma
- Publication
Molecules, 2019, Vol 24, Issue 17, p3127
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24173127