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- Title
Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.
- Authors
Wei-Hua Jiao; Jing Li; Qian Liu; Ting-Ting Xu; Guo-Hua Shi; Hao-Bing Yu; Fan Yang; Bing-Nan Han; Min Li; Hou-Wen Lin
- Abstract
An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) with MIC90 values of 8.0 µg/mL against both.
- Subjects
SOUTH China Sea; SPONGES (Invertebrates); STAPHYLOCOCCUS aureus infections; SPECTROSCOPIC imaging; ANTIBACTERIAL agents; PATHOGENIC bacteria; DIAGNOSIS
- Publication
Molecules, 2014, Vol 19, Issue 11, p18025
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules191118025