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- Title
Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives.
- Authors
Barea, Carlos; Pabón, Adriana; Galiano, Silvia; Pérez-Silanes, Silvia; Gonzalez, German; Deyssard, Chloe; Monge, Antonio; Deharo, Eric; Aldana, Ignacio
- Abstract
Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.
- Subjects
MALARIA; LEISHMANIASIS; ANTIMALARIALS; PLASMODIUM falciparum; COMMUNICABLE diseases
- Publication
Molecules, 2012, Vol 17, Issue 8, p9451
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17089451