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- Title
Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata.
- Authors
Hai-Liang Xin; Xiao-Feng Zhai; Xu Zheng; Lei Zhang; Yu-Liang Wang; Zhuo Wang
- Abstract
The present study was undertaken to investigate the anti-inflammatory and analgesic activity of total flavone of branches and leaves of Cunninghamia lanceolata (TFC) to provide a scientific basis for its clinical use and resource development. TFC was evaluated for anti-inflammatory and analgesic activity in mice or rats using chemical and thermal models of nociception, including acetic acid-induced writhing test, hot plate latency test, formalin test and carrageenan induced paw oedema test. Results showed that TFC given orally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, TFC showed common activity in prolonging duration time only at the highest dose (400 mg/kg). Each dose of TFC could not significantly inhibit the first phase but was active in the later phase of formalin-induced pain, whereas morphine showed notable activity in the two phases. In the carrageenan-induced paw oedema model, TFC could significantly and dose-dependently reduce the carrageenan-induced paw edema at the third and fifth hour, and decrease the content of PEG2 in paw edema tissue and that of COX-2 in blood serum. It may be concluded that TFC showed both anti-inflammatory and analgesic effects, showing that it can be of importance in drug development, especially in the field of pain and inflammation.
- Subjects
ANTI-inflammatory agents; CHINA fir; ANALGESICS; FLAVONES; CARRAGEENANS; EDEMA; LABORATORY rats
- Publication
Molecules, 2012, Vol 17, Issue 8, p8842
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17088842