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- Title
p-Cymene Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammatory Cell Activation.
- Authors
Guanghong Xie; Na Chen; Wassy Soromou, Lanan; Fang Liu; Ying Xiong; Qianchao Wu; Hongyu Li; Haihua Feng; Guowen Liu
- Abstract
The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice.
- Subjects
CYMENE; LABORATORY mice; LIPOPOLYSACCHARIDES; LUNG injuries; TUMOR necrosis factors; MITOGEN-activated protein kinases; MYELOPEROXIDASE
- Publication
Molecules, 2012, Vol 17, Issue 7, p8159
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17078159