We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Study of Hematological Parameters and Morphometric Indices of Erythrocytes in Rats Exposed to Calcium Oxide Nanoparticles.
- Authors
Zemlyanova, M. A.; Zaitseva, N. V.; Ignatova, A. M.; Stepankov, M. S.; Toropov, L. I.; Kol'dibekova, Yu. V.
- Abstract
In female Wistar rats, we studied the effects of daily 20-day administration of intragastric suspension of nanosized calcium oxide on hematological indices (the counts of erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, basophils, lymphocytes, monocytes, stab/segmented neutrophils, and the eosinophil-to-lymphocyte ratio) and morphometric parameters of erythrocytes (equivalent Feret's diameter, sphericity, aspect ratio, and convexity). The study revealed significantly (up to 3.1 times) decreased levels of hemoglobin, platelets, hematocrit, averaged content of hemoglobin in erythrocyte, and platelet volume relatively to the control values. The established morphometric parameters of blood erythrocytes attested to predominance of spherocytes, which can be regarded as systemic response of the body to calcium oxide nanoparticles fraught with possible deterioration of perfusion in microvasculature and hypoxia in the tissues.
- Subjects
LIME (Minerals); ERYTHROCYTES; LABORATORY rats; CALCIUM in the body; BLOOD platelets; LEUCOCYTES
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 170, Issue 5, p665
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05128-0