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- Title
In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin.
- Authors
Kuzmin, D. V.; Emel’yanova, A. A.; Kalashnikova, M. B.; Panteleev, P. V.; Ovchinnikova, T. V.
- Abstract
We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.
- Subjects
CISPLATIN; TACHYPLESIN; ANTI-infective agents; CANCER cells; HUMAN cell cycle
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 2, p220
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4134-6