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- Title
Changes in Lipid Metabolism during Walker 256 Tumor Growth and the Therapeutic Effect of Hyperthermia.
- Authors
Efremov, A.; Khegai, I.; Molokov, K.; Pakhomova, Yu.
- Abstract
The dynamics of lipoprotein content during Walker 256 tumor growth in rats was studied. Moderate changes in HDL and LDL were paralleled by signifi cant changes in VLDL level. A 2-fold increase of VLDL in comparison with the intact control was recorded on day 10 of tumor growth. Exposure to total hyperthermia additionally stimulated VLDL synthesis and this parameter increased by 4 times and more in rats with tumors in comparison with controls. This effect of hyperthermia correlated with signifi cant subsequent decrease of rat mortality caused by the lethal effect of the tumor.
- Subjects
LIPID metabolism; TUMOR growth; FEVER; LABORATORY rats; VERY low-density lipoproteins; MORTALITY
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 156, Issue 6, p838
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2464-6