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- Title
EFFICACY OF SALVIA OFFICINALIS AS AN EXPERIMENTAL APPLICATION OF COSMETIC SURGERY IN RATS MODEL.
- Authors
Jassim, Ali Ismail; Al Haideri, Dhurgham Hameed; Munahi, Ahmed K.; Aziz, Omar Khalid
- Abstract
Cosmetic surgeries for pets might include wrinkle removal, tail docking, ear trimming, declawing in felines, debarking in canines, and hair dying. The herein experiment was conducted to evaluate the effects of sage leaf ethanolic extract powder (SLEEP) on the skin amino acid profile and skin wrinkling in white Albino rats. The experiment was carried out using 30. White, albino rats (15 fed 80mg/kg B.W./day for 30 days, group 1 (G1) and 15 received no treatment, (G2). Skin biopsy samples were taken at day-0, day-14 and day-30 for checking the skin amino acid profile (SAAP), glycine, alanine, proline and hydroxyproline and skin histopathological biopsy samples were collected at day-30 of the experiment for evaluating the skin wrinkling (length and diameter). The outcomes demonstrated that the SAAP in G1 showed significant (p<0.05) increases when the levels in the samples taken on day-14 and day-30 were compared to those from day-0. No differences were seen in the samples collected at all day-time points from G2. For the histopathological analysis, the findings revealed significant (p<0.05) lower lengths and diameters of the skin wrinkles in the samples of G1 when compared to those from G2. The results provide evidences that the use of the sage leaf extract may enhance skin care via increase in the amino acid profile of the skin especially in the levels of glycine, alanine, proline, and hydroxyproline. Moreover, the extract may induce improvements in the skin care via decreasing the skin wrinkle reads.
- Subjects
PLASTIC surgery; SKIN biopsy; SAGE; HYDROXYPROLINE; GLYCINE
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 1, p1707
- ISSN
0972-5075
- Publication type
Article