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- Title
Stem cell-derived intestinal organoids: a novel modality for IBD.
- Authors
Tian, Cheng-mei; Yang, Mei-feng; Xu, Hao-ming; Zhu, Min-zheng; Yue, Ning-Ning; Zhang, Yuan; Shi, Rui-yue; Yao, Jun; Wang, Li-sheng; Liang, Yu-jie; Li, De-feng
- Abstract
The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissue and organ. Using the regeneration ability of stem cells, a 3D organ-like structure called intestinal organoids is established, which can mimic the characteristics of real intestinal organs, including morphology, function, and personalized response to specific stimuli. Here, we discuss current stem cell-based organ-like 3D intestinal models, including understanding the molecular pathophysiology, high-throughput screening drugs, drug efficacy testing, toxicological evaluation, and organ-based regeneration of inflammatory bowel disease (IBD). We summarize the advances and limitations of the state-of-the-art reconstruction platforms for intestinal organoids. The challenges, advantages, and prospects of intestinal organs as an in vitro model system for precision medicine are also discussed.
- Subjects
INFLAMMATORY bowel diseases; INTESTINES; ORGANOIDS; HIGH throughput screening (Drug development); DRUG efficacy
- Publication
Cell Death Discovery, 2023, Vol 9, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-023-01556-1