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- Title
Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders.
- Authors
Handen, Benjamin; Johnson, Cynthia; Butter, Eric; Lecavalier, Luc; Scahill, Lawrence; Aman, Michael; McDougle, Christopher; Arnold, L.; Swiezy, Naomi; Sukhodolsky, Denis; Mulick, James; White, Susan; Bearss, Karen; Hollway, Jill; Stigler, Kimberly; Dziura, James; Yu, Sunkyung; Sacco, Kelley; Vitiello, Benedetto
- Abstract
A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4-13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition ( p = .0002) and 12 % increase in compliance to parental requests ( p = .004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement ( p = .001) and fewer repeated requests for compliance ( p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement ( p = .01) and fewer restrictive statements ( p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures.
- Subjects
UNITED States; RISPERIDONE; ANALYSIS of covariance; STATISTICAL correlation; SCIENTIFIC observation; HEALTH outcome assessment; PARENT-child relationships; QUESTIONNAIRES; RESEARCH funding; RANDOMIZED controlled trials; TREATMENT effectiveness; PERVASIVE child development disorders; DATA analysis software; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
Journal of Developmental & Physical Disabilities, 2013, Vol 25, Issue 3, p355
- ISSN
1056-263X
- Publication type
Article
- DOI
10.1007/s10882-012-9316-y