We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?
- Authors
Ciura, Krzesimir; Ptaszyńska, Natalia; Kapica, Hanna; Pastewska, Monika; Łęgowska, Anna; Rolka, Krzysztof; Kamysz, Wojciech; Sawicki, Wiesław; Greber, Katarzyna E.
- Abstract
The emergence and spread of multiple drug-resistant bacteria strains caused the development of new antibiotics to be one of the most important challenges of medicinal chemistry. Despite many efforts, the commercial availability of peptide-based antimicrobials is still limited. The presented study aims to explain that immobilized artificial membrane chromatography can support the characterization of antimicrobial peptides. Consequently, the chromatographic experiments of three groups of related peptide substances: (i) short cationic lipopeptides, (ii) citropin analogs, and (iii) conjugates of ciprofloxacin and levofloxacin, with a cell-penetrating peptide were discussed. In light of the discussion of the mechanisms of action of these compounds, the obtained results were interpreted.
- Subjects
ARTIFICIAL membranes; PEPTIDE derivatives; CHROMATOGRAPHIC analysis; ANTIMICROBIAL peptides; PHARMACEUTICAL chemistry; PEPTIDE antibiotics
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 10, p1237
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10101237