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- Title
BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19.
- Authors
Ji, Rui-Ru; Qu, Yajin; Zhu, Hua; Yang, Yumei; Vogel, Annette B.; Sahin, Ugur; Qin, Chuan; Hui, Aimin; Lee, Soo-Hong; Park, Hansoo; Rajendran, Jagathesh Chandra; Jaganathan, K. S.
- Abstract
BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
- Subjects
COVID-19; SARS-CoV-2; COVID-19 vaccines; TRANSGENIC mice; LUNG diseases
- Publication
Vaccines, 2021, Vol 9, Issue 4, p324
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines9040324