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- Title
Lifetime Risk Factors for Pre- and Post-Bronchodilator Lung Function Decline. A Population-based Study.
- Authors
Bui, Dinh S.; Perret, Jennifer L.; Walters, E. Haydn; Abramson, Michael J.; Burgess, John A.; Bui, Minh Q.; Bowatte, Gayan; Lowe, Adrian J.; Russell, Melissa A.; Alif, Sheikh M.; Thompson, Bruce R.; Hamilton, Garun S.; Giles, Graham G.; Thomas, Paul S.; Morrison, Stephen; Johns, David P.; Knibbs, Luke D.; Zock, Jan-Paul; Marcon, Alessandro; Garcia-Aymerich, Judith
- Abstract
Rationale: Interactions between early life and adult insults on lung function decline are not well understood, with most studies investigating prebronchodilator (pre-BD) FEV1 decline.Objectives: To investigate relationships between adult risk factors and pre- and post-BD lung function decline and their potential effect modification by early life and genetic factors.Methods: Multiple regression was used to examine associations between adult exposures (asthma, smoking, occupational exposures, traffic pollution, and obesity) and decline in both pre- and post-BD spirometry (forced expiratory volume in 1 s [FEV1], forced vital capacity [FVC], and FEV1/FVC) between ages 45 and 53 years in the Tasmanian Longitudinal Health Study (n = 857). Effect modification of these relationships by childhood respiratory risk factors, including low childhood lung function and GST (glutathione S-transferase) gene polymorphisms, was investigated.Results: Baseline asthma, smoking, occupational exposure to vapors/gases/dusts/fumes, and living close to traffic were associated with accelerated decline in both pre- and post-BD FEV1. These factors were also associated with FEV1/FVC decline. Occupational exposure to aromatic solvents was associated with pre-BD but not post-BD FEV1 decline. Maternal smoking accentuated the effect of personal smoking on pre- and post-BD FEV1 decline. Lower childhood lung function and having the GSTM1 null allele accentuated the effect of occupational exposure to vapors/gases/dusts/fumes and personal smoking on post-BD FEV1 decline. Incident obesity was associated with accelerated decline in FEV1 and more pronounced in FVC.Conclusions: This study provides new evidence for accentuation of individual susceptibility to adult risk factors by low childhood lung function, GSTM1 genotype, and maternal smoking.
- Subjects
PULMONARY function tests; DISEASE risk factors; BRONCHODILATOR agents; GENETIC polymorphisms; ASTHMA; OBESITY; RESEARCH; DUST; GASES; LUNGS; LUNG diseases; RESEARCH methodology; SOCIAL networks; RESPIRATORY measurements; OCCUPATIONAL exposure; REGRESSION analysis; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; PSYCHOLOGICAL tests; FORCED expiratory volume; TRANSFERASES; DISEASE susceptibility; QUESTIONNAIRES; RESEARCH funding; SMOKING; SPIROMETRY; LONGITUDINAL method; PHARMACODYNAMICS
- Publication
Annals of the American Thoracic Society, 2020, Vol 17, Issue 3, p302
- ISSN
2329-6933
- Publication type
journal article
- DOI
10.1513/AnnalsATS.201904-329OC