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- Title
Serum levels of adiponutrin in differentiating non-alcoholic steatohepatitis from simple steatosis in non-alcoholic fatty liver disease patients.
- Authors
Shukla, Mayuri; Kunder, Mamatha; Kamarthy, Prabhakar; Balakrishna, Sharath
- Abstract
Background and aims: Non-alcoholic fatty liver disease is one of a chronic liver diseases, characterized by an unusual accumu- lation of fats in hepatocytes. It's a multifactorial disease and the pathogenesis is not completely known. The genetic association is seen, where the patatin-like phospholipase domain-containing protein 3 (PNPLA3) is the most relevant genetic association. PNPLA3 encodes for a protein called adiponutrin (ADPN), which has triglyceride hydrolase and acyltransferase activity. Hepatic fat accumulation results due to excess lipogenesis or decreased fat export. Liver biopsy is the only gold standard available for differentiating the stages of NAFLD, but it's an invasive procedure that may lead to potential infections. The study aimed to eval- uate serum levels of ADPN in stages of NAFLD. Materials and methods: This is an observational study comprised of 60 NAFLD cases, among which 10 subjects were stage 1 (simple steatosis) and 50 subjects stage 2 (non-alcoholic steatohepatitis-NASH). Blood samples were collected from the subjects and serum ADPN levels were assessed by enzyme-linked immunosorbent assay. Results: The serum levels of ADPN were significantly decreased in NASH as compared to simple steatosis (p<0.00l). Conclu- sions: ADPN serum level was inversely associated with the progression of NAFLD.
- Subjects
NON-alcoholic fatty liver disease; FATTY degeneration; ACYLTRANSFERASES; ENZYME-linked immunosorbent assay; LIVER diseases; LIVER biopsy
- Publication
Romanian Journal of Diabetes Nutrition & Metabolic Diseases, 2022, Vol 29, Issue 2, p261
- ISSN
2068-8245
- Publication type
Article
- DOI
10.46389/rjd-2022-1101