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- Title
Searching the Missing Link Between Alzheimer's Disease and Diabetes.
- Authors
Mitrea, Adina; Popa, Simona Georgiana; Muntean, Cristina; Soare, Andreea; Trotta, Laura; Callea, Antonio; Moţa, Maria
- Abstract
Recent studies strongly suggest a significant association between diabetes mellitus and Alzheimer Disease (AD) justifying the term 'type 3 diabetes'. Studies show that impairment of glucose metabolism occurs very early in the course of AD, leading to a broad range of consequences, among which the accumulation of amyloid beta (Aβ), which per se induces insulin resistance. Furthermore, adipocytokines, recognised markers of insulin resistance, seem to play a role in the development of AD. As for insulin resistance, when AD is considered, the most studied ones are leptin and adiponectin, but also a recently described adipokine - progranulin. It is our belief that both prospective and transversal studies on subjects with both AD and type 2 diabetes (T2D) may prove the role of adipokines not only in AD, but also in this most somber association.
- Publication
Romanian Journal of Diabetes Nutrition & Metabolic Diseases, 2013, Vol 20, Issue 2, p177
- ISSN
2068-8245
- Publication type
Article
- DOI
10.2478/rjdnmd-2013-0022