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- Title
Genetics of Anxiety and Stress-Related Disorders-Toward a Bottom-up Cross-Disorder Psychopathology.
- Authors
Domschke, Katharina; Gottschalk, Michael G.
- Abstract
Gene-based tests reinforced a role of I PDE4B i and, most importantly, the GWAS top hit (rs7528604; an intronic single-nucleotide polymorphism [SNP], with the major G allele conferring increased anxiety or stress-related disorder susceptibility) survived resampling analyses that removed individuals with comorbid major depressive disorder (MDD), suggesting an association free of interference from affective spectrum risk genes. The joint SNP heritability of anxiety and stress-related disorders was estimated at a substantial 0.28 (SE, 0.027), emphasizing a complex phenotype shaped by genetic and environmental effects. The results strongly imply that anxiety and stress-related disorders harbor a principal, yet still elusive, common trunk signature of genetic risk loci that leads to altered neurobiological pathways and processes, observed on the phenotypic level as affective spectrum comorbidity and reflected by a shared quantifiable heritability.[7].
- Subjects
ANXIETY disorders; GENETICS; CLASSIFICATION of mental disorders; GENETIC epidemiology; CYCLIC adenylic acid; NEUROSES; ANIMALS; ANXIETY; MICE; PATHOLOGICAL psychology; SEQUENCE analysis
- Publication
JAMA Psychiatry, 2019, Vol 76, Issue 9, p889
- ISSN
2168-622X
- Publication type
editorial
- DOI
10.1001/jamapsychiatry.2019.0998