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- Title
A comprehensive manually-curated compendium of bovine transcription factors.
- Authors
de Souza, Marcela M.; Zerlotini, Adhemar; Geistlinger, Ludwig; Tizioto, Polyana C.; Taylor, Jeremy F.; Rocha, Marina I. P.; Diniz, Wellison J. S.; Coutinho, Luiz L.; Regitano, Luciana C. A.
- Abstract
Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
- Publication
Scientific Reports, 2018, Vol 8, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-018-32146-2