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- Title
Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies.
- Authors
Micarelli, David; Ranalli, Teresa Valentina; Taddei, Anna Rita; Solazzo, Angela; Moccia, Francesca; Feriozzi, Sandro
- Abstract
Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by progressive loss of renal function in a short period. At renal biopsy, it is characterized by crescent formation. RPGN may be associated with the presence of circulating antibodies. We report a case of type IV RPGN [ANCA and Anti-glomerular basement membrane (anti-GBM) antibody disease], a severe disease causing a difficult to treat picture. Our case was complicated by severe thrombocytopenia due to the use of heparin and later on by thrombotic microangiopathy. These events occurred rapidly, making the clinical framing and management decisions very hard.
- Subjects
AUTOANTIBODIES; GLOMERULONEPHRITIS; BASAL lamina; RENAL biopsy; IMMUNOGLOBULINS; HEPATORENAL syndrome; THROMBOTIC thrombocytopenic purpura
- Publication
Journal of Nephropathology, 2020, Vol 9, Issue 3, p1
- ISSN
2251-8363
- Publication type
Article
- DOI
10.34172/jnp.2020.30