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- Title
Allergic and irritant contact dermatitis compared in the treatment of alopecia totalis and universalis. A comparison of the value of topical diphencyprone and tretinoin gel.
- Authors
Ashworth, J.; Tuyp, E.; Mackie, Rona M.
- Abstract
Diphencyprone is a potent topical sensitizer, but is non-mutagenic in the Ames test (unlike dinitrochlorobenzene) and remains relatively stable in solution (unlike squaric acid dibutyl ester). Seventeen patients with total loss of scalp hair (eight alopecia total is, nine alopecia universalis) were treated by maintaining on one side of the scalp an allergic contact dermatitis induced by 2,3 diphenylcyclopropenone- z (`diphencyprone'), and on the other side an irritant contact dermatitis using tretanoin gel (Retin A). After 20 weeks, treatment with trennoin was stopped and diphencyprone was applied bilaterally for a further to weeks. Satisfactory regrowth of terminal hair on the scalp was achieved in only one patient. Eyebrow, eyelash and beard regrowth was achieved in one individual whilst in another, moderate, but not cosmetically satisfactory, scalp regrowth took place. In no patient did regrowth take place at tretinoin treated sites until after diphencypronc was substituted.
- Subjects
DERMATOLOGIC agents; CONTACT dermatitis; SKIN inflammation; BALDNESS; RETINOIDS; TRETINOIN; ALLERGY drug therapy
- Publication
British Journal of Dermatology, 1989, Vol 120, Issue 3, p397
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1989.tb04166.x