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- Title
Role of the cytoskeleton in communication between L-type Ca<sup>2+</sup> channels and mitochondria.
- Authors
Viola, Helena M; Hool, Livia C
- Abstract
The L-type Ca2+ channel is the main route for Ca2+ entry into cardiac myocytes, which is essential for the maintenance of cardiac excitation and contraction. Alterations in L-type Ca2+ channel activity and Ca2+ homeostasis have been implicated in the development of cardiomyopathies., Cardiac excitation and contraction is fuelled by ATP, synthesized predominantly by the mitochondria via the Ca2+-dependent process oxidative phosphorylation. Mitochondrial reactive oxygen species ( ROS) are by-products of oxidative phosphorylation and are associated with the development of cardiac pathology., The cytoskeleton plays a role in the communication of signals from the plasma membrane to intracellular organelles. There is good evidence that both L-type Ca2+ channel activity and mitochondrial function can be modulated by changes in the cytoskeletal network., Activation of the L-type Ca2+ channel can regulate mitochondrial function through cytoskeletal proteins as a result of transmission of movement from the β2-subunit of the channel that occurs during activation and inactivation of the channel. An association between cytoskeletal proteins and the mitochondrial voltage-dependent anion channel ( VDAC) may play a role in this response., The L-type Ca2+ channel is the initiator of contraction in cardiac muscle and the VDAC is responsible for regulating mitochondrial ATP/ ADP trafficking. This article presents evidence that a functional coupling between L-type Ca2+ channels and mitochondria may assist in meeting myocardial energy demand on a beat-to-beat basis.
- Subjects
CYTOSKELETON; CARDIAC hypertrophy; CARDIOMYOPATHIES; PHOSPHORYLATION; MITOCHONDRIA
- Publication
Clinical & Experimental Pharmacology & Physiology, 2013, Vol 40, Issue 4, p295
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/1440-1681.12072