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- Title
Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-κB-inhibiting activity.
- Authors
Mazur, Igor; Wurzer, Walter J.; Ehrhardt, Christina; Pleschka, Stephan; Puthavathana, Pilaipan; Silberzahn, Tobias; Wolff, Thorsten; Planz, Oliver; Ludwig, Stephan
- Abstract
Influenza is still one of the major plagues worldwide. The statistical likeliness of a new pandemic outbreak highlights the urgent need for new and amply available antiviral drugs. We and others have shown that influenza virus misuses the cellular IKK/NF-κB signalling pathway for efficient replication suggesting that this module may be a suitable target for antiviral intervention. Here we examined acetylsalicylic acid (ASA), also known as aspirin, a widely used drug with a well-known capacity to inhibit NF-κB. We show that the drug efficiently blocks influenza virus replication in vitro and in vivo in a mechanism involving impaired expression of proapoptotic factors, subsequent inhibition of caspase activation as well as block of caspase-mediated nuclear export of viral ribonucleoproteins. As ASA showed no toxic side-effects or the tendency to induce resistant virus variants, existing salicylate-based aerosolic drugs may be suitable as anti-influenza agents. This is the first demonstration that specific targeting of a cellular factor is a suitable approach for anti-influenza virus intervention.
- Subjects
ASPIRIN; INFLUENZA; ANTIVIRAL agents; MICROBIOLOGY; ANALGESICS
- Publication
Cellular Microbiology, 2007, Vol 9, Issue 7, p1683
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/j.1462-5822.2007.00902.x