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- Title
The Concerted Modulation of Proliferation and Migration Contributes to the Specification of the Cytoarchitecture and Dimensions of Cortical Areas.
- Authors
Lukaszewicz, Agnès; Cortay, Véronique; Giroud, Pascale; Berland, Michel; Smart, Iain; Kennedy, Henry; Dehay, Colette
- Abstract
Regionalization of cell cycle kinetics of cortical precursors has been described in nonhuman primates and rodents indicating a fate map of areas as distinct proliferative programs in the germinal zones of the neocortex. It remains to be understood how proliferative gradients during corticogenesis are transcribed into a stepwise function to form adult areal borders. Here we have used the monkey areas 17 and 18, which show striking cytoarchitectonic differences, as a model system for studying how developmental events establish areal boundaries in the adult. We present data indicating that the events that are involved in the formation of a sharp border separating 2 areas involve an orchestration of diverse phenomena including differential rates of proliferation, migration, and tangential expansion.
- Publication
Cerebral Cortex, 2006, Vol 16, Issue suppl_1, pi26
- ISSN
1047-3211
- Publication type
Article
- DOI
10.1093/cercor/bhk011