Found: 29
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Alzheimer's disease: strategies for disease modification.
- Published in:
- 2010
- By:
- Publication type:
- journal article
Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.
- Published in:
- 2019
- By:
- Publication type:
- journal article
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
- Published in:
- Nature Medicine, 2003, v. 9, n. 1, p. 3, doi. 10.1038/nm0103-3
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- Publication type:
- Article
Anti-Inflammatory Drug Therapy Alters Β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease.
- Published in:
- Journal of Neuroscience, 2003, v. 23, n. 20, p. 7504, doi. 10.1523/JNEUROSCI.23-20-07504.2003
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- Publication type:
- Article
Current directions in tau research: Highlights from Tau 2020.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 988, doi. 10.1002/alz.12452
- By:
- Publication type:
- Article
O4‐05‐05: PREVENTION OF TAU SEEDING AND SPREADING IN TRANSGENIC MOUSE MODELS BASED ON INTRACRANIAL‐INJECTION OF P301L‐K18 FIBRILS OR ALZHEIMER'S DISEASE LYSATE BY PASSIVE IMMUNOTHERAPY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1412, doi. 10.1016/j.jalz.2018.06.2937
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- Publication type:
- Article
Strategies for disease modification in Alzheimer's disease.
- Published in:
- Nature Reviews Neuroscience, 2004, v. 5, n. 9, p. 677, doi. 10.1038/nrn1495
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- Publication type:
- Article
T807, a reported selective tau tracer, binds with nanomolar affinity to monoamine oxidase a.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P283, doi. 10.1016/j.jalz.2015.07.381
- By:
- Publication type:
- Article
Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease
- Published in:
- 2012
- By:
- Publication type:
- Abstract
BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs)
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Central BACE1 inhibition by LY2886721 produces opposing effects on APP processing as reflected by cerebrospinal fluid sAPPalpha and sAPPbeta
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Central BACE1 inhibition by LY2886721 produces opposing effects on APP processing as reflected by cerebrospinal fluid sAPP-alpha and sAPP-beta
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Central and peripheral pharmacodynamic effects of BACE1 inhibition following oral administration of LY2811376 to PDAPP mice and beagle dog
- Published in:
- 2010
- By:
- Publication type:
- Abstract
S4-01-03: Beta-secretase (BACE1) as a predictor of risk in Alzheimer disease: High levels of BACE1 in cerebrospinal fluid of mild cognitive impairment
- Published in:
- 2006
- By:
- Publication type:
- Abstract
PL-02-02: Beta-secretase as a therapeutic target
- Published in:
- 2006
- By:
- Publication type:
- Abstract
S4-01-03: Beta-secretase (BACE1) as a predictor of risk in Alzheimer disease: High levels of BACE1 in cerebrospinal fluid of mild cognitive impairment
- Published in:
- 2006
- By:
- Publication type:
- Abstract
PL-02-02: Beta-secretase as a therapeutic target
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-...
- Published in:
- Nature, 1992, v. 360, n. 6405, p. 672, doi. 10.1038/360672a0
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- Publication type:
- Article
Identifying Proteases That Cleave APP.
- Published in:
- Annals of the New York Academy of Sciences, 2000, v. 920, n. 1, p. 192, doi. 10.1111/j.1749-6632.2000.tb06921.x
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- Publication type:
- Article
β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 14, p. 3639, doi. 10.1523/JNEUROSCI.4396-06.2007
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- Publication type:
- Article
β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
- Published in:
- FEBS Journal, 2010, v. 277, n. 6, p. 1503, doi. 10.1111/j.1742-4658.2010.07579.x
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- Publication type:
- Article
Reply to Matters Arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease.
- Published in:
- NPJ Parkinson's Disease, 2024, p. 1, doi. 10.1038/s41531-024-00658-6
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- Publication type:
- Article
In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease.
- Published in:
- NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00552-7
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- Publication type:
- Article
Alzheimer's disease: treatments in discovery and development.
- Published in:
- Nature Neuroscience, 2002, v. 5, n. 11, p. 1055, doi. 10.1038/nn940
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- Publication type:
- Article
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation.
- Published in:
- Nature Neuroscience, 2001, v. 4, n. 3, p. 231, doi. 10.1038/85059
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- Publication type:
- Article
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
- Published in:
- European Journal of Neuroscience, 2006, v. 23, n. 1, p. 251, doi. 10.1111/j.1460-9568.2005.04551.x
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- Publication type:
- Article
The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets.
- Published in:
- PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0182887
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- Publication type:
- Article